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Boosting BCG with MVA85A: the first candidate subunit vaccine for tuberculosis in clinical trials.

Abstract:

There is an urgent need for an improved vaccine against tuberculosis. Heterologous prime-boost immunization regimes induce higher levels of cellular immunity than homologous boosting with the same vaccine. Using BCG as the priming immunization in such a regime allows for the retention of the beneficial protective effects of BCG against disseminated disease in childhood. Recombinant poxviruses are powerful boosting agents, for both CD4+ and CD8+ T cells. Here we review the preclinical data fro...

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Publication status:
Published

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Publisher copy:
10.1016/j.tube.2004.09.015

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Pathan, AA More by this author
Sander, CR More by this author
Goonetilleke, NP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Journal:
Tuberculosis (Edinburgh, Scotland)
Volume:
85
Issue:
1-2
Pages:
47-52
Publication date:
2005
DOI:
EISSN:
1873-281X
ISSN:
1472-9792
URN:
uuid:e9ab8b59-e978-4e3b-bf71-8492d17b2158
Source identifiers:
32977
Local pid:
pubs:32977

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