- Abstract:
-
IFN-gamma regulates the immunogenicity of target cells by increasing their expression of HLA class I molecules. This facilitates the T cell receptor-mediated recognition by CD8(+) T cells but decreases target cell sensitivity to lysis by NK cells due to engagement of inhibitory NK receptors. In this study, short-term tumor cell lines from patients with advanced ovarian carcinomas were established. We demonstrate the paradoxical finding that IFN-gamma treatment of these short-term ovarian carc...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1172/jci0215564
-
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- Journal:
- The Journal of clinical investigation
- Volume:
- 110
- Issue:
- 10
- Pages:
- 1515-1523
- Publication date:
- 2002-11-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:e9a1512a-9c3c-4478-8e19-7f8ae963c659
- Source identifiers:
-
434245
- Local pid:
- pubs:434245
- Language:
- English
- Keywords:
- Copyright date:
- 2002
Journal article
IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.
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