Journal article icon

Journal article

IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

Abstract:

IFN-gamma regulates the immunogenicity of target cells by increasing their expression of HLA class I molecules. This facilitates the T cell receptor-mediated recognition by CD8(+) T cells but decreases target cell sensitivity to lysis by NK cells due to engagement of inhibitory NK receptors. In this study, short-term tumor cell lines from patients with advanced ovarian carcinomas were established. We demonstrate the paradoxical finding that IFN-gamma treatment of these short-term ovarian carc...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1172/jci0215564

Authors


Malmberg, KJ More by this author
Levitsky, V More by this author
de Matos, CT More by this author
Carlsten, M More by this author
Expand authors...
Journal:
The Journal of clinical investigation
Volume:
110
Issue:
10
Pages:
1515-1523
Publication date:
2002-11-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:e9a1512a-9c3c-4478-8e19-7f8ae963c659
Source identifiers:
434245
Local pid:
pubs:434245

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP