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Hyporesponsiveness of intestinal dendritic cells to TLR stimulation is limited to TLR4.

Abstract:

Dendritic cells (DCs) are crucial to intestinal immune regulation because of their roles in inducing protective immunity against pathogens while maintaining tolerance to commensal bacteria. Nonetheless, relatively little is known about intestinal DC responsiveness to innate immune stimuli via TLRs. We have previously shown that DCs migrating from the rat intestine in lymph (iLDCs) are hyporesponsive to LPS stimulation, thus possibly preventing harmful immune responses being induced to commens...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.0802318

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
182
Issue:
4
Pages:
2405-2415
Publication date:
2009-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e9a0bf0a-c762-4155-8ff6-e11b797595a1
Source identifiers:
11405
Local pid:
pubs:11405

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