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Plasmodium berghei: plasmodium perforin-like protein 5 is required for mosquito midgut invasion in Anopheles stephensi.

Abstract:

During its life cycle the malarial parasite Plasmodium forms three invasive stages which have to invade different and specific cells for replication to ensue. Invasion is vital to parasite survival and consequently proteins responsible for invasion are considered to be candidate vaccine/drug targets. Plasmodium perforin-like proteins (PPLPs) have been implicated in invasion because they contain a predicted pore-forming domain. Ookinetes express three PPLPs, and one of them (PPLP3) has previou...

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Authors


Kafatos, FC More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Experimental parasitology
Volume:
116
Issue:
4
Pages:
504-508
Publication date:
2007-08-05
DOI:
EISSN:
1090-2449
ISSN:
0014-4894
URN:
uuid:e99c05aa-a6ca-4dd5-a86b-d12d8da8c6e4
Source identifiers:
267040
Local pid:
pubs:267040

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