Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria.

Journal article

PURPOSE: We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria. METHODS: Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twe...

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Authors: Lee, S; Mcgready, R; Fernandez, C; Stepniewska, K; Paw, M

• Publication status: Published
• Journal: European journal of clinical pharmacology
• Volume: 64
• Issue: 10
• Pages: 987-992
• Publication date: 2008-10-01
• DOI: 10.1007/s00228-008-0500-z
• EISSN: 1432-1041
• ISSN: 0031-6970
• Language: English
• Keywords: Adolescent; Area Under Curve; Pregnancy Complications, Parasitic; Malaria, Vivax; Pregnancy Outcome; Chloroquine; Plasmodium vivax; Retrospective Studies; Thailand; Pregnancy; Pregnancy Trimester, Third; Acute Disease; Young Adult; Female; Humans; Adult; Antimalarials; Pregnancy Trimester, Second; Animals