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Rapamycin in ischemic stroke: Old drug, new tricks?

Abstract:

The significant morbidity that accompanies stroke makes it one of the world's most devastating neurological disorders. Currently, proven effective therapies have been limited to thrombolysis and thrombectomy. The window for the administration of these therapies is narrow, hampered by the necessity of rapidly imaging patients. A therapy that could extend this window by protecting neurons may improve outcome. Endogenous neuroprotection has been shown to be, in part, due to changes in mTOR signa...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1177/0271678X18807309

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Harris Manchester College
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Investigative Medicine Division
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Investigative Medicine Division
Oxford college:
St Hilda's College
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Somerville College
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Oxford college:
Somerville College
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Funding agency for:
Hadley, G
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Funding agency for:
Adriaanse, B
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Funding agency for:
Sutherland, B
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Publisher:
SAGE Publications Publisher's website
Journal:
Journal of Cerebral Blood Flow and Metabolism Journal website
Volume:
39
Issue:
1
Pages:
20-35
Publication date:
2018-10-18
Acceptance date:
2018-09-06
DOI:
EISSN:
1559-7016
ISSN:
0271-678X
Pubs id:
pubs:924499
URN:
uri:e9918f20-4a90-424d-bd32-a7910a8ae045
UUID:
uuid:e9918f20-4a90-424d-bd32-a7910a8ae045
Local pid:
pubs:924499

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