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Journal article

Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells.

Abstract:

p21-activated kinases (PAKs) are serine/threonine protein kinases that serve as important mediators of Rac and Cdc42 GTPase function as well as pathways required for Ras-driven tumorigenesis. PAK1 has been implicated in signaling by growth factor receptors and morphogenetic processes that control cell polarity, invasion, and actin cytoskeleton organization. To better understand the role of PAK1 in tumorigenesis, PAK1 genomic copy number and expression were determined for a large panel of brea...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1103350108

Authors


Haverty, PM More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
108
Issue:
17
Pages:
7177-7182
Publication date:
2011-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:e9909c0d-6818-460e-88fc-25f01e0998f8
Source identifiers:
149816
Local pid:
pubs:149816

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