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Journal article

Apolipoprotein E genotype, islet amyloid deposition and severity of Type 2 diabetes.

Abstract:

Islet amyloid is found in 90% of patients with Type 2 (non-insulin-dependent) diabetes at post-mortem. More extensive amyloidosis is associated with decreased islet function and requirement for insulin therapy. Severity of cerebral amyloidosis in Alzheimer's disease (AD) is increased in subjects with the apolipoprotein E (ApoE) epsilon 4 allele. To determine if ApoE genotype was associated with severity of islet amyloidosis and diabetes, samples were genotyped from 32 specimens of post-mortem...

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Publication status:
Published

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Authors


Powell, DS More by this author
Maksoud, H More by this author
Chargé, SB More by this author
Moffitt, JH More by this author
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Journal:
Diabetes research and clinical practice
Volume:
60
Issue:
2
Pages:
105-110
Publication date:
2003-05-05
DOI:
EISSN:
1872-8227
ISSN:
0168-8227
URN:
uuid:e98a2934-5f21-4c5e-9116-5463d2f192cb
Source identifiers:
32354
Local pid:
pubs:32354

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