Journal article icon

Journal article

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain of mouse P-glycoprotein: structure-activity relationships for flavonoid binding.

Abstract:

Sequence requirements of the ATP-binding site within the C-terminal nucleotide-binding domain (NBD2) of mouse P-glycoprotein were investigated by using two recombinantly expressed soluble proteins of different lengths and photoactive ATP analogues, 8-azidoadenosine triphosphate (8N(3)-ATP) and 2',3',4'-O-(2,4,6-trinitrophenyl)-8-azidoadenosine triphosphate (TNP-8N(3)-ATP). The two proteins, Thr(1044)-Thr(1224) (NBD2(short)) and Lys(1025)-Ser(1276) (NBD2(long)), both incorporated the four cons...

Expand abstract

Actions


Access Document


Publisher copy:
10.1021/bi010657c

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
McIntosh, DB More by this author
Conseil, G More by this author
Baubichon-Cortay, H More by this author
Expand authors...
Journal:
Biochemistry
Volume:
40
Issue:
34
Pages:
10382-10391
Publication date:
2001-08-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:e9887f4b-5a54-41c3-bb30-193027f3d503
Source identifiers:
237365
Local pid:
pubs:237365

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP