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Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

Abstract:

Identification of the signaling pathways that regulate cyclic nucleotide microdomains is essential to our understanding of cardiac physiology and pathophysiology. Although there is growing evidence that the plasma membrane Ca(2+)/calmodulin-dependent ATPase 4 (PMCA4) is a regulator of neuronal nitric-oxide synthase, the physiological consequence of this regulation is unclear. We therefore tested the hypothesis that PMCA4 has a key structural role in tethering neuronal nitric-oxide synthase to...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m111.290411

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Journal:
Journal of biological chemistry More from this journal
Volume:
286
Issue:
48
Pages:
41520-41529
Publication date:
2011-12-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258

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