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Longitudinal COVID-19 profiling associates IL-1Ra and IL-10 with disease severity and RANTES with mild disease

Abstract:

Background Identifying immune correlates of COVID-19 disease severity is an urgent need for clinical management, vaccine evaluation and drug development. Here we present a temporal analysis of key immune mediators, cytokine and chemokines in blood of hospitalised COVID-19 patients from serial sampling and follow up over four weeks.

Methods A total of 71 patients with laboratory-confirmed COVID-19 admitted to Beijing You’an hospital in China with ei...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/jci.insight.139834

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More from this funder
Name:
Royal Society
Grant:
NI140175
More from this funder
Name:
Wellcome Trust
Grant:
097813/Z/11/A
More from this funder
Name:
Medical Research Council
Grant:
MR/L018942/1
Publisher:
American Society for Clinical Investigation
Journal:
JCI Insight More from this journal
Volume:
5
Issue:
13
Article number:
e139834
Publication date:
2020-06-05
Acceptance date:
2020-06-03
DOI:
EISSN:
2379-3708
Language:
English
Keywords:
Pubs id:
1108783
Local pid:
pubs:1108783
Deposit date:
2020-06-03

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