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Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

Abstract:

The TREK subfamily of two-pore domain (K2P) K+ channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the “up” and “down” conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluoxe...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1085/jgp.201611601

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Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics, Condensed Matter Physics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Structural Genomics Consortium
Baukrowitz, T More by this author
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Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of General Physiology Journal website
Volume:
147
Issue:
6
Pages:
497-505
Publication date:
2016-05-30
DOI:
EISSN:
1540-7748
ISSN:
0022-1295
URN:
uuid:e96e673e-61b8-41ce-a8e1-89d7b15c02e8
Source identifiers:
625393
Local pid:
pubs:625393
Language:
English

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