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5-HTT binding in recovered depressed patients and healthy volunteers: a positron emission tomography study with [11C]DASB.

Abstract:

OBJECTIVE: The serotonin transporter (5-HTT) is a key target for selective serotonin reuptake inhibitors and may be involved in the pathophysiology of major depression. It is now possible to image 5-HTT directly in the human brain, but results from studies of acutely depressed patients have been inconsistent. The purpose of this study was to determine whether abnormalities in 5-HTT might be present in recovered depressed patients. METHOD: The authors measured the binding potential of 5-HTT us...

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Publication status:
Published

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Journal:
The American journal of psychiatry
Volume:
164
Issue:
12
Pages:
1858-1865
Publication date:
2007-12-05
DOI:
EISSN:
1535-7228
ISSN:
0002-953X
URN:
uuid:e9646d63-45bd-4ee9-8ffc-545d8a617157
Source identifiers:
139677
Local pid:
pubs:139677

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