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S-adenosylmethionine in rat liver cirrhosis

Abstract:
An experimental model of cirrhosis in rats, by means carbon tetrachloride (CCl4) and ethanol during two months, was used to assess the effectiveness of S-adenosylmethionine. Histological studies of the liver and examination of different biochemical parameters of hepatic function were also employed. Bilirubin and lactic acid levels decreased significantly in the group treated with S-adenosylmethionine in comparison with the CCl4 + ethanol group. Histologic liver studies showed a significant improvement relative to fatty liver, Mallory bodies, infiltrate polymorphonuclear and perivenular fibrosis. A slight decrease in cirrhosis was observed in the animals treated with S- adenosylmethionine.

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Department:
Unknown
Role:
Author


Journal:
Research Communications in Substances of Abuse More from this journal
Volume:
14
Issue:
2-3
Pages:
159-167
Publication date:
1993-01-01
ISSN:
0193-0818


Language:
English
Pubs id:
pubs:410715
UUID:
uuid:e9635d72-c3e6-40e2-aeef-c68ad43dae12
Local pid:
pubs:410715
Source identifiers:
410715
Deposit date:
2013-11-16
ARK identifier:

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