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Journal article

Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.

Abstract:

Pyrophosphate and diphosphonates produce striking results on calcium metabolism in experimental animals and man. Compounds containing P-O-P- bonds (e.g. inorganic pyrophosphate [PP-ii1 or P-C-P bonds (diphosponates) inhibit both the formation and dissolution of calcium phosphate crystals in vitro. PP-i may have a physiological function in regulating calcification and bone turnover, and obnormalities in its metabolism may occur in some human diseases notably hypophosphatasia and pseudogout. Di...

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Publication status:
Published

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Journal:
Clinical orthopaedics and related research
Volume:
no. 108
Issue:
108
Pages:
241-263
Publication date:
1975-05-05
EISSN:
1528-1132
ISSN:
0009-921X
URN:
uuid:e960c1d5-af98-4e1c-8a18-788de1849c62
Source identifiers:
109384
Local pid:
pubs:109384

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