Journal article icon

Journal article

Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.

Abstract:

Pyrophosphate and diphosphonates produce striking results on calcium metabolism in experimental animals and man. Compounds containing P-O-P- bonds (e.g. inorganic pyrophosphate [PP-ii1 or P-C-P bonds (diphosponates) inhibit both the formation and dissolution of calcium phosphate crystals in vitro. PP-i may have a physiological function in regulating calcification and bone turnover, and obnormalities in its metabolism may occur in some human diseases notably hypophosphatasia and pseudogout. Di...

Expand abstract
Publication status:
Published

Actions


Authors


Journal:
Clinical orthopaedics and related research
Volume:
no. 108
Issue:
108
Pages:
241-263
Publication date:
1975-05-01
EISSN:
1528-1132
ISSN:
0009-921X
Source identifiers:
109384

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP