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Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint.

Abstract:

X-irradiation-induced DNA damage perturbs the G(1), S, and G(2) phases of the cell cycle. The behavior of cells after they have experienced a DNA damage checkpoint delay is poorly characterized. We therefore examined the fates of irradiated tumor cells that have overcome a prolonged G(2) checkpoint delay. Most irradiated cells progressed through mitosis without significant delay, but failed to complete cytokinesis as they remained tethered to each other at the midbody. We observed that the mo...

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Publication status:
Published

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Journal:
Cancer research More from this journal
Volume:
68
Issue:
10
Pages:
3724-3732
Publication date:
2008-05-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Keywords:
Pubs id:
pubs:131226
UUID:
uuid:e960b328-878c-4b37-afec-ed98f5471961
Local pid:
pubs:131226
Source identifiers:
131226
Deposit date:
2012-12-19

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