Journal article
Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).
- Abstract:
-
Repeated subconvulsant doses of the GABA antagonist drugs picrotoxin (5 mg/kg), pentylenetetrazol (PTZ) (30 mg/kg), and bicuculline (3.5 mg/kg), were given IP once daily to rats. Picrotoxin produced rapid kindling to full seizures in about 5 days, PTZ produced sporadic myoclonic seizures after 17 days, PTZ produced sporadic myoclonic seizures after 17 days whereas bicuculline only produced occasional mild jerking. Following these treatments, seizure thresholds to these drugs were measured by ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1007/bf00430762
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Authors
Bibliographic Details
- Publisher:
- Springer-Verlag
- Journal:
- Psychopharmacology
- Volume:
- 76
- Issue:
- 1
- Pages:
- 84-87
- Publication date:
- 1982-01-01
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- Source identifiers:
-
185966
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:185966
- UUID:
-
uuid:e95f4aea-f54d-478a-8853-425ff7547afd
- Local pid:
- pubs:185966
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1982
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