Journal article icon

Journal article

Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).

Abstract:

Repeated subconvulsant doses of the GABA antagonist drugs picrotoxin (5 mg/kg), pentylenetetrazol (PTZ) (30 mg/kg), and bicuculline (3.5 mg/kg), were given IP once daily to rats. Picrotoxin produced rapid kindling to full seizures in about 5 days, PTZ produced sporadic myoclonic seizures after 17 days, PTZ produced sporadic myoclonic seizures after 17 days whereas bicuculline only produced occasional mild jerking. Following these treatments, seizure thresholds to these drugs were measured by ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/bf00430762

Authors


Publisher:
Springer-Verlag
Journal:
Psychopharmacology
Volume:
76
Issue:
1
Pages:
84-87
Publication date:
1982-01-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Source identifiers:
185966
Language:
English
Keywords:
Pubs id:
pubs:185966
UUID:
uuid:e95f4aea-f54d-478a-8853-425ff7547afd
Local pid:
pubs:185966
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP