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Repeated administration of subconvulsant doses of GABA antagonist drugs. I. Effect on seizure threshold (kindling).

Abstract:

Repeated subconvulsant doses of the GABA antagonist drugs picrotoxin (5 mg/kg), pentylenetetrazol (PTZ) (30 mg/kg), and bicuculline (3.5 mg/kg), were given IP once daily to rats. Picrotoxin produced rapid kindling to full seizures in about 5 days, PTZ produced sporadic myoclonic seizures after 17 days, PTZ produced sporadic myoclonic seizures after 17 days whereas bicuculline only produced occasional mild jerking. Following these treatments, seizure thresholds to these drugs were measured by ...

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Publication status:
Published

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Publisher copy:
10.1007/bf00430762

Authors


Publisher:
Springer-Verlag
Journal:
Psychopharmacology
Volume:
76
Issue:
1
Pages:
84-87
Publication date:
1982-01-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:e95f4aea-f54d-478a-8853-425ff7547afd
Source identifiers:
185966
Local pid:
pubs:185966

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