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Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition.

Abstract:

Vertebral fracture risk is a heritable complex trait. The aim of this study was to identify genetic susceptibility factors for osteoporotic vertebral fractures applying a genome-wide association study (GWAS) approach. The GWAS discovery was based on the Rotterdam Study, a population-based study of elderly Dutch individuals aged >55years; and comprising 329 cases and 2,666 controls with radiographic scoring (McCloskey-Kanis) and genetic data. Replication of one top-associated SNP was pursue...

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Publisher copy:
10.1016/j.bone.2013.10.015

Authors


Estrada, K More by this author
Duncan, EL More by this author
Christiansen, C More by this author
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Journal:
Bone
Publication date:
2013-10-05
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
URN:
uuid:e95c1393-a0bc-456b-be88-6c18aca4ec90
Source identifiers:
472438
Local pid:
pubs:472438

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