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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Abstract:

BH4 (tetrahydrobiopterin) supplementation improves endothelial function in models of vascular disease by maintaining eNOS (endothelial nitric oxide synthase) coupling and NO (nitric oxide) bioavailability. However, the cellular mechanisms through which enhanced endothelial function leads to reduced atherosclerosis remain unclear. We have used a pharmaceutical BH4 formulation to investigate the effects of BH4 supplementation on atherosclerosis progression in ApoE-KO (apolipoprotein E-knockout)...

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Publication status:
Published

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Publisher copy:
10.1042/cs20090559

Authors


Schmidt, TS More by this author
McNeill, E More by this author
Douglas, G More by this author
Crabtree, MJ More by this author
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Journal:
Clinical science (London, England : 1979)
Volume:
119
Issue:
3
Pages:
131-142
Publication date:
2010-08-05
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
URN:
uuid:e95b80a6-1b25-4ec1-a3f3-91ac47feb943
Source identifiers:
105336
Local pid:
pubs:105336

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