Journal article icon

Journal article

Structural determinants of integrin recognition by talin.

Abstract:

The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand...

Expand abstract

Actions


Access Document


Authors


Journal:
Molecular cell More from this journal
Volume:
11
Issue:
1
Pages:
49-58
Publication date:
2003-01-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Language:
English
Keywords:
Pubs id:
pubs:246384
UUID:
uuid:e955ed93-662d-4621-9966-a6f56b29fddf
Local pid:
pubs:246384
Source identifiers:
246384
Deposit date:
2013-11-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP