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Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.

Abstract:

The Krebs cycle enzyme fumarate hydratase (FH) is a human tumor suppressor whose inactivation is associated with the development of leiomyomata, renal cysts, and tumors. It has been proposed that activation of hypoxia inducible factor (HIF) by fumarate-mediated inhibition of HIF prolyl hydroxylases drives oncogenesis. Using a mouse model, we provide genetic evidence that Fh1-associated cyst formation is Hif independent, as is striking upregulation of antioxidant signaling pathways revealed by...

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Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2011.09.006

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Hatipoglu, E More by this author
O'Flaherty, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Jenner Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Human Genetics Wt Centre
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Journal:
Cancer cell
Volume:
20
Issue:
4
Pages:
524-537
Publication date:
2011-10-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:e950f729-b481-4f43-a73d-f80d52047178
Source identifiers:
191334
Local pid:
pubs:191334

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