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Journal article

Importance of collection tube during clinical studies of oseltamivir.

Abstract:
Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step: incubation at 60 degrees C for 45 min.
Publication status:
Published

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Publisher copy:
10.1128/aac.01534-06

Authors


Lindegardh, N More by this author
Davies, GR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Singhasivanon, P More by this author
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Journal:
Antimicrobial agents and chemotherapy
Volume:
51
Issue:
5
Pages:
1835-1836
Publication date:
2007-05-05
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
URN:
uuid:e94fa061-a72c-428d-a227-c14562569e5d
Source identifiers:
10523
Local pid:
pubs:10523

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