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STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE

Abstract:
Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with the purified ACV synthetase from C. acremonium gave exclusive incorporation of a single 18O label into ACV, consistent witheffectively non-reversible formation of a covalent valinoyl-ACV synthetase intermediate under in vitro conditions. © 1992.
Publication status:
Published

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Journal:
TETRAHEDRON More from this journal
Volume:
48
Issue:
6
Pages:
1099-1108
Publication date:
1992-02-07
DOI:
ISSN:
0040-4020
Language:
English
Keywords:
Pubs id:
pubs:43845
UUID:
uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6
Local pid:
pubs:43845
Source identifiers:
43845
Deposit date:
2012-12-19

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