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Quantitative in vitro demonstration of two-photon photodynamic therapy using photofrin and visudyne.

Abstract:

Photodynamic therapy (PDT), the combined action of a photosensitizer and light to produce a cytotoxic effect, is an approved therapy for a number of diseases. At present, clinical PDT treatments involve one-photon excitation of the photosensitizer. A major limitation is that damage may be caused to healthy tissues that have absorbed the drug and lie in the beam path. Two-photon excitation may minimize this collateral damage, as the probability of absorption increases with the square of the li...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Photochemistry and photobiology More from this journal
Volume:
83
Issue:
6
Pages:
1441-1448
Publication date:
2007-01-01
DOI:
EISSN:
1751-1097
ISSN:
0031-8655
Language:
English
Keywords:
Pubs id:
pubs:51794
UUID:
uuid:e942f896-9d8d-4f54-b6db-94821fecef7d
Local pid:
pubs:51794
Source identifiers:
51794
Deposit date:
2012-12-19

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