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TGF-β in transplantation tolerance

Abstract:

TGF-β is a cytokine required for the induction and maintenance of transplantation tolerance in animal models. TGF-β mediates anti-inflammatory effects by acting on many immune cell-types. Central for transplantation tolerance is the role for TGF-β in the induction of Foxp3 and regulatory capacity in CD4 + T cells. Recently, however, the general anti-inflammatory role of TGF-β in CD4 + T cell polarization was questioned by the discovery that, in the presence of inflammatory cytokines such as I...

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Publisher copy:
10.1016/j.coi.2011.07.003

Authors


Regateiro, FS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Waldmann, H More by this author
Journal:
Current Opinion in Immunology
Volume:
23
Issue:
5
Pages:
660-669
Publication date:
2011-10-05
DOI:
EISSN:
1879-0372
ISSN:
0952-7915
URN:
uuid:e93a329d-02b8-4317-95fc-619451bef21f
Source identifiers:
192946
Local pid:
pubs:192946
Language:
English

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