- Abstract:
-
TGF-β is a cytokine required for the induction and maintenance of transplantation tolerance in animal models. TGF-β mediates anti-inflammatory effects by acting on many immune cell-types. Central for transplantation tolerance is the role for TGF-β in the induction of Foxp3 and regulatory capacity in CD4 + T cells. Recently, however, the general anti-inflammatory role of TGF-β in CD4 + T cell polarization was questioned by the discovery that, in the presence of inflammatory cytokines such as I...
Expand abstract - Publisher copy:
- 10.1016/j.coi.2011.07.003
-
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- Journal:
- Current Opinion in Immunology
- Volume:
- 23
- Issue:
- 5
- Pages:
- 660-669
- Publication date:
- 2011-10-05
- DOI:
- EISSN:
-
1879-0372
- ISSN:
-
0952-7915
- URN:
-
uuid:e93a329d-02b8-4317-95fc-619451bef21f
- Source identifiers:
-
192946
- Local pid:
- pubs:192946
- Language:
- English
- Copyright date:
- 2011
Journal article
TGF-β in transplantation tolerance
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