TGF-β in transplantation tolerance

Journal article

TGF-β is a cytokine required for the induction and maintenance of transplantation tolerance in animal models. TGF-β mediates anti-inflammatory effects by acting on many immune cell-types. Central for transplantation tolerance is the role for TGF-β in the induction of Foxp3 and regulatory capacity in CD4 + T cells. Recently, however, the general anti-inflammatory role of TGF-β in CD4 + T cell polarization was questioned by the discovery that, in the presence of inflammatory cytokines such as IL-6 or IL-1, TGF-β drives the differentiation of Th17 cells associated with transplant rejection. A better understanding of the factors determining TGF-β production and activation, Foxp3 induction and Treg stability is vital for the development of tolerogenic strategies in transplantation. © 2011 Elsevier Ltd.

Authors: Regateiro, F; Howie, D; Cobbold, S; Waldmann, H

• Journal: Current Opinion in Immunology
• Volume: 23
• Issue: 5
• Pages: 660-669
• Publication date: 2011-10-01
• DOI: 10.1016/j.coi.2011.07.003
• EISSN: 1879-0372
• ISSN: 0952-7915
• Language: English