Journal article
Heterocycle-derived β-S-enals as bifunctional linchpins for the catalytic synthesis of saturated heterocycles
- Abstract:
- We demonstrate how heterocycle-derived β-S-enals can be employed as bifunctional substrates in a cascade of two rhodium-catalysed C–C bond forming reactions to deliver substituted heterocyclic products. A single rhodium-catalyst, generated in situ from a commercial salt and ligand combination, is used to promote both an initial alkene or alkyne hydroacylation reaction, and then a Suzuki-type cross-coupling, resulting in a three-component assembly of the targeted heterocycles. Substrates based on N-, O- and S-heterocycles are included, as are a range of alkenes, alkynes and boronic acid derivatives.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.1MB, Terms of use)
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- Publisher copy:
- 10.1039/c6qo00057f
Authors
+ Engineering and Physical Sciences Research Council
More from this funder
- Funding agency for:
- Willis, M
- Grant:
- Established Career Fellowship
- Publisher:
- Royal Society of Chemistry
- Journal:
- Organic chemistry frontiers : an international journal of organic chemistry / Royal Society of Chemistry More from this journal
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-03-11
- DOI:
- ISSN:
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2052-4129
- Pubs id:
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pubs:611156
- UUID:
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uuid:e932a94e-024d-4f33-b715-9603fafc5b6b
- Local pid:
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pubs:611156
- Source identifiers:
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611156
- Deposit date:
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2016-03-21
- ARK identifier:
Terms of use
- Copyright holder:
- Niu and Willis
- Copyright date:
- 2016
- Notes:
- This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
- Licence:
- CC Attribution (CC BY)
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