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STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13.

Abstract:

STCP-1 stimulated T cell chemoattractant protein-1 (STCP-1) (macrophage-derived chemokine; MDC), a recently described CC chemokine for chronically activated T lymphocytes, was found to act specifically on a subset of memory CD4 lymphocytes that displayed a Th2 cytokine profile. Also, STCP-1, thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in vitro derived Th2 lymphocytes, while IP-10 (IFN-gamma-inducible 10-kDa protein) showed some preference for...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
161
Issue:
9
Pages:
5027-5038
Publication date:
1998-11-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:e931d9c6-403c-4fcc-a3ca-7011dff43666
Source identifiers:
246809
Local pid:
pubs:246809

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