STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13.

Journal article

STCP-1 stimulated T cell chemoattractant protein-1 (STCP-1) (macrophage-derived chemokine; MDC), a recently described CC chemokine for chronically activated T lymphocytes, was found to act specifically on a subset of memory CD4 lymphocytes that displayed a Th2 cytokine profile. Also, STCP-1, thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in vitro derived Th2 lymphocytes, while IP-10 (IFN-gamma-inducible 10-kDa protein) showed some preference for Th1 lymphocytes. The corresponding receptors for eotaxin, TARC, and IP-10 are also differentially expressed on Th1 and Th2 lymphocytes. In desensitization Ca flux experiments, TARC and STCP-1 bound to a common receptor and therefore at least one chemokine receptor for STCP-1 is CCR4. STCP-1 expression is restricted to immune cells. Dendritic cells, B cells, and macrophages produce STCP-1 constitutively, while NK cells, monocytes, and CD4 lymphocytes produce STCP-1 upon appropriate stimulation. Production of STCP-1 is positively modulated by Th2 cytokines IL-4 and IL-13 but inhibited by IL-10.

Authors: Andrew, D; Chang, MS; McNinch, J; Wathen, S; Rihanek, M

• Publication status: Published
• Journal: Journal of Immunology
• Volume: 161
• Issue: 9
• Pages: 5027-5038
• Publication date: 1998-11-01
• EISSN: 1550-6606
• ISSN: 0022-1767
• Language: English
• Keywords: Chemokine CCL5; Immunologic Memory; Interleukin-4; Mice, Inbred BALB C; Interleukin-13; Chemokine CCL24; Chemokine CCL17; Mice; Receptors, CXCR3; Animals; Chemotaxis, Leukocyte; Receptors, CCR4; Humans; Chemokines, CC; B-Lymphocytes; Granulocyte-Macrophage Colony-Stimulating Factor; Chemokines; Macrophages; Chemokines, CXC; Monocytes; Feedback; Calcium Signaling; Cytokines; Receptors, CCR3; Lymphocyte Activation; Killer Cells, Natural; Chemokine CXCL10; Chemokine CCL22; Dendritic Cells; Interleukin-10; Chemokine CCL11; Receptors, Chemokine