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A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

Abstract:

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent in people of African and Asian origin than Caucasian origin. FcgammaRIIb is an inhibitory Fc receptor with a critical role in immune regulation. Mouse data suggest that FcgammaRIIb deficiency increases susceptibility to autoimmune disease but protects against infection. We show that a SNP in human FCGR2B that abrogates receptor function is strongly associated with susceptibility to SLE in both Caucasians and...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0915133107

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
107
Issue:
17
Pages:
7881-7885
Publication date:
2010-04-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424

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