Journal article icon

Journal article

A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus

Abstract:

The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. To better understand the molecular basis for immune recognition, we raised a class of neutralizing monoclonal antibodies (nAbs) against RVFV Gn, which exhibited protective efficacy in a mouse infection model. Structural characterization revealed that these nAbs were directed to the membrane-distal domain of RVFV Gn a...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2018.12.001

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
BDI-NDM
Role:
Author
ORCID:
0000-0001-8538-4995
Expand authors...
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
13
Pages:
3750-3758
Publication date:
2018-12-26
Acceptance date:
2018-11-29
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:954582
URN:
uri:e92e894b-4bf5-4b11-91d0-ad85c0658ae1
UUID:
uuid:e92e894b-4bf5-4b11-91d0-ad85c0658ae1
Local pid:
pubs:954582

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP