Journal article
A protective monoclonal antibody targets a site of vulnerability on the surface of Rift Valley fever virus
- Abstract:
-
The Gn subcomponent of the Gn-Gc assembly that envelopes the human and animal pathogen, Rift Valley fever virus (RVFV), is a primary target of the neutralizing antibody response. To better understand the molecular basis for immune recognition, we raised a class of neutralizing monoclonal antibodies (nAbs) against RVFV Gn, which exhibited protective efficacy in a mouse infection model. Structural characterization revealed that these nAbs were directed to the membrane-distal domain of RVFV Gn a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 25
- Issue:
- 13
- Pages:
- 3750-3758
- Publication date:
- 2018-12-26
- Acceptance date:
- 2018-11-29
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- Pmid:
-
30590046
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:954582
- UUID:
-
uuid:e92e894b-4bf5-4b11-91d0-ad85c0658ae1
- Local pid:
- pubs:954582
- Source identifiers:
-
954582
- Deposit date:
- 2019-01-16
Terms of use
- Copyright holder:
- Allen et al
- Copyright date:
- 2018
- Notes:
- © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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