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Serum cortisol and 17-hydroxyprogesterone interrelation in classic 21-hydroxylase deficiency: is current replacement therapy satisfactory?

Abstract:

One of the main aims in the management of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency is to achieve adequate suppression of the adrenal cortex with the smallest possible dose of glucocorticoid substitution. To evaluate the administration schedule of current replacement therapy regimens, we investigated the cortisol-17-hydroxyprogesterone interrelation in 36 patients (13 males and 23 females; median age, 12.3 yr; range, 6.1-18.8 yr) with salt-wasting congenita...

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Publication status:
Published

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Publisher copy:
10.1210/jc.86.10.4679

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
10
Pages:
4679-4685
Publication date:
2001-10-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Source identifiers:
72950
Language:
English
Keywords:
Pubs id:
pubs:72950
UUID:
uuid:e92e00db-fd48-4b7b-8b36-2642e9522f10
Local pid:
pubs:72950
Deposit date:
2012-12-19

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