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Serum cortisol and 17-hydroxyprogesterone interrelation in classic 21-hydroxylase deficiency: is current replacement therapy satisfactory?

Abstract:

One of the main aims in the management of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency is to achieve adequate suppression of the adrenal cortex with the smallest possible dose of glucocorticoid substitution. To evaluate the administration schedule of current replacement therapy regimens, we investigated the cortisol-17-hydroxyprogesterone interrelation in 36 patients (13 males and 23 females; median age, 12.3 yr; range, 6.1-18.8 yr) with salt-wasting congenita...

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Publication status:
Published

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Publisher copy:
10.1210/jc.86.10.4679

Authors


Charmandari, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Johnston, A More by this author
Hindmarsh, PC More by this author
Journal:
The Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
10
Pages:
4679-4685
Publication date:
2001-10-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:e92e00db-fd48-4b7b-8b36-2642e9522f10
Source identifiers:
72950
Local pid:
pubs:72950

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