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Is there an association between NPY and neuroticism?

Abstract:

Psychiatric genetics has been hampered by the fact that initially exciting findings from underpowered studies are so often not replicated in larger, more powerful, data sets. Here we show that the claims of Zhou et al. that neuropeptide Y (NPY) diplotype-predicted expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting of phenotypically extreme individuals drawn from a large (n = 88,142) non-clinical population. We found no association between NPY ...

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Publication status:
Published

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Publisher copy:
10.1038/nature07927

Authors


Cotton, CH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Campbell, TG More by this author
Journal:
Nature
Volume:
458
Issue:
7238
Pages:
E6-E7
Publication date:
2009-04-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:e921534a-a758-4200-931a-73154b4d3387
Source identifiers:
34671
Local pid:
pubs:34671

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