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Journal article

PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.

Abstract:

Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cel...

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Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2004.08.034

Authors


Björndahl, MA More by this author
Clasper, S More by this author
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Journal:
Cancer cell
Volume:
6
Issue:
4
Pages:
333-345
Publication date:
2004-10-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:e91e1050-9cd5-4b94-aaac-f8a8cd431417
Source identifiers:
102739
Local pid:
pubs:102739

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