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Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

Abstract:

Refined crystal structures are reported for complexes of Escherichia coli and chicken dihydrofolate reductase containing the antibiotic trimethoprim (TMP). Structural comparison of these two complexes reveals major geometrical differences in TMP binding that may be important in understanding the stereo-chemical basis of this inhibitor's selectivity for bacterial dihydrofolate reductases. For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-d...

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Publication status:
Published

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Authors


Matthews, DA More by this author
Burridge, JM More by this author
Filman, DJ More by this author
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Journal:
The Journal of biological chemistry
Volume:
260
Issue:
1
Pages:
381-391
Publication date:
1985-01-05
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:e91b4e73-d4c8-4d8d-a0fa-c6ff5bb13269
Source identifiers:
72665
Local pid:
pubs:72665

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