Journal article
Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.
- Abstract:
-
Refined crystal structures are reported for complexes of Escherichia coli and chicken dihydrofolate reductase containing the antibiotic trimethoprim (TMP). Structural comparison of these two complexes reveals major geometrical differences in TMP binding that may be important in understanding the stereo-chemical basis of this inhibitor's selectivity for bacterial dihydrofolate reductases. For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-d...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of biological chemistry
- Volume:
- 260
- Issue:
- 1
- Pages:
- 381-391
- Publication date:
- 1985-01-01
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- Source identifiers:
-
72665
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:72665
- UUID:
-
uuid:e91b4e73-d4c8-4d8d-a0fa-c6ff5bb13269
- Local pid:
- pubs:72665
- Deposit date:
- 2012-12-19
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- Copyright date:
- 1985
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