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Journal article

USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.

Abstract:

The E3 ubiquitin ligase Mule/ARF-BP1 plays an important role in the cellular DNA damage response by controlling base excision repair and p53 protein levels. However, how the activity of Mule is regulated in response to DNA damage is currently unknown. Here, we report that the Ser18-containing isoform of the USP7 deubiquitylation enzyme (USP7S) controls Mule stability by preventing its self-ubiquitylation and subsequent proteasomal degradation. We find that in response to DNA damage, downregul...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/nar/gks1359

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Role:
Author
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Funding agency for:
Dianov, GL
Cancer Research UK More from this funder
Medical Research Council More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Nucleic acids research Journal website
Volume:
41
Issue:
3
Pages:
1750-1756
Publication date:
2013-02-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:e91a502e-050a-4014-88d0-ab4911f50bff
Source identifiers:
369887
Local pid:
pubs:369887

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