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Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons.

Abstract:

Striatal dopamine plays key roles in our normal and pathological goal-directed actions. To understand dopamine function, much attention has focused on how midbrain dopamine neurons modulate their firing patterns. However, we identify a presynaptic mechanism that triggers dopamine release directly, bypassing activity in dopamine neurons. We paired electrophysiological recordings of striatal channelrhodopsin2-expressing cholinergic interneurons with simultaneous detection of dopamine release at...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Deisseroth, K More by this author
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Journal:
Neuron
Volume:
75
Issue:
1
Pages:
58-64
Publication date:
2012-07-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:e91910d7-aa92-4c49-8736-835259f1f2b0
Source identifiers:
342335
Local pid:
pubs:342335

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