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The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men.

Abstract:

In the present study, we have determined the relative frequency of the R46L, I474V and E670G variants in the PCSK9 (protein convertase subtilisin/kexin type 9) gene and its association with plasma lipid levels and CHD (coronary heart disease) in healthy U.K. men and patients with clinically defined definite FH (familial hypercholesterolaemia). Genotypes were determined using PCR and restriction enzyme digestion in 2444 healthy middle-aged (50-61 years) men from the prospective NPHSII (Second ...

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Publisher copy:
10.1042/cs20070150

Authors


Journal:
Clinical science (London, England : 1979) More from this journal
Volume:
113
Issue:
11
Pages:
435-441
Publication date:
2007-12-01
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
Language:
English
Keywords:
Pubs id:
pubs:94984
UUID:
uuid:e918b525-1260-41da-be58-d8976f526e91
Local pid:
pubs:94984
Source identifiers:
94984
Deposit date:
2012-12-19

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