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DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Abstract:

Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is involved in cell differentiation, proliferation, and apoptosis, and was recently shown to be regulated by hypoxia. The present immunohistochemical study demonstrates extensive nuclear expression of the protein in 38% of a series of 115 non-small cell lung carcinomas using a polyclonal antibody (Ab) recognizing DEC1 protein. Such expression was directly related to the expression of two hypoxia-regulated proteins, namely the hypoxia-i...

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Publication status:
Published

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Publisher copy:
10.1002/path.1330

Authors


Giatromanolaki, A More by this author
Koukourakis, MI More by this author
Sivridis, E More by this author
Wykoff, CC More by this author
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Journal:
The Journal of pathology
Volume:
200
Issue:
2
Pages:
222-228
Publication date:
2003-06-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:e915f3a5-97e4-48b8-bd56-eda20afef89e
Source identifiers:
119429
Local pid:
pubs:119429

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