Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease

Journal article

Parkinson's disease (PD) is a neurological, chronic and progressive disease that affects the patient's central nervous system, thus compromising their movements and routine activities. There are several surgical interventions to minimize the symptoms of the disease, however, deep brain stimulation (DBS) can be used, as it is effective in reducing motor and non-motor symptoms, however, research shows that the technique can also cause side effects. Objective: to report through a literature review, the positive and negative effects of the use of deep brain stimulation in the treatment of Parkinson's disease on motor and non-motor symptoms. Methodology: Theoretical foundation was carried out from online access to the National Library of Medicine database - PubMed MEDLINE, covering the keywords "brain stimulation", "Parkinson's disease", "treatment", "neurosurgery", "motor and non-motor symptoms”, the period of publication between 2018 to 2022 and journal impact factor above 3. Results: The articles demonstrated that patients' quality of life, motor complications and activities of daily living improved significantly in different age groups after bilateral STN-DBS. For non-motor factors such as sleep, mood, cardiovascular disease and depression, the use of DBS showed little significant improvement in quality of life. Final considerations: Treatment with deep brain stimulation is effective in reducing the progression of Parkinson's disease, however, factors such as age, place where the electrical current is applied (lateral, bilateral), use of levodopa are decisive factors for efficiency in the improvement of motor and non-motor symptoms

Authors: Jost, ST; Visser-Vandewalle, V; Rizos, A; Loehrer, PA; Silverdale, M

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Nature Research
• Journal: npj Parkinson's Disease
• Volume: 7
• Issue: 1
• Pages: 48-48
• Article number: 48
• Publication date: 2021-06-08
• DOI: 10.1038/s41531-021-00174-x
• EISSN: 2373-8057
• ISSN: 2373-8057
• Language: English
• Keywords: Disease; Quality of life (healthcare); Physical medicine and rehabilitation; Stimulation; Deep brain stimulation; Psychology; Internal medicine; Medicine; Subthalamic nucleus; Parkinson's disease; Neuroscience