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Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing

Abstract:

Malaria elimination strategies require surveillance of the parasite population for genetic changes that demand a public health response, such as new forms of drug resistance. Here we describe methods for the large-scale analysis of genetic variation in Plasmodium falciparum by deep sequencing of parasite DNA obtained from the blood of patients with malaria, either directly or after short-term culture. Analysis of 86,158 exonic single nucleotide polymorphisms that passed genotyping quality con...

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Publisher copy:
10.1038/nature11174

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Nature More from this journal
Volume:
487
Issue:
7407
Pages:
375-379
Publication date:
2012-07-19
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Pubs id:
pubs:344517
UUID:
uuid:e9055604-111a-45c8-b2f1-890e3b93c2a8
Local pid:
pubs:344517
Source identifiers:
344517
Deposit date:
2012-12-19

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