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Meta-analysis of gene-level tests for rare variant association

Abstract:

The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population structure and repeated small-sample analyses sharing individual-level data. As the focus of genetic association studies shifts to rare variants, genes and other functional units are becoming the focus of analysis. Here we propose and evaluate new a...

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Publisher copy:
10.1038/ng.2852

Authors


Peloso, GM More by this author
Holmen, OL More by this author
Zawistowski, M More by this author
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Publisher:
Nature Publishing Group
Journal:
Nature Genetics
Volume:
46
Issue:
2
Pages:
200-204
Publication date:
2014
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:e9030041-62e8-4184-b6c5-6128a4f4cedc
Source identifiers:
472200
Local pid:
pubs:472200
Language:
English

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