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Genome-wide evidence for selection acting on single amino acid repeats.

Abstract:

Low complexity and homopolymer sequences within coding regions are known to evolve rapidly. While their expansion may be deleterious, there is increasing evidence for a functional role associated with these amino acid sequences. Homopolymer sequences are thought to evolve mostly through replication slippage and, therefore, they may be expected to be longer in regions with relaxed selective constraint. Within the coding sequences of eukaryotes, alternatively spliced exons are known to evolve u...

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Publisher copy:
10.1101/gr.101246.109

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Genome research More from this journal
Volume:
20
Issue:
6
Pages:
755-760
Publication date:
2010-06-01
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
Language:
English
Keywords:
Pubs id:
pubs:237582
UUID:
uuid:e90205af-f6ab-4faf-8451-e5bab667c96d
Local pid:
pubs:237582
Source identifiers:
237582
Deposit date:
2012-12-19

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