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Journal article

Epidemic dynamics and antigenic evolution in a single season of influenza A.

Abstract:

We use a mathematical model to study the evolution of influenza A during the epidemic dynamics of a single season. Classifying strains by their distance from the epidemic-originating strain, we show that neutral mutation yields a constant rate of antigenic evolution, even in the presence of epidemic dynamics. We introduce host immunity and viral immune escape to construct a non-neutral model. Our population dynamics can then be framed naturally in the context of population genetics, and we sh...

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Publication status:
Published

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Publisher copy:
10.1098/rspb.2006.3466
Journal:
Proceedings. Biological sciences / The Royal Society More from this journal
Volume:
273
Issue:
1592
Pages:
1307-1316
Publication date:
2006-06-01
DOI:
EISSN:
1471-2954
ISSN:
0962-8452
Language:
English
Keywords:
Pubs id:
pubs:125409
UUID:
uuid:e90157f8-8a3a-4daf-8be9-4f3b66838a48
Local pid:
pubs:125409
Source identifiers:
125409
Deposit date:
2012-12-19

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