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Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.

Abstract:

To evaluate glucose kinetics in children with falciparum malaria, basal glucose production and gluconeogenesis and an estimate of the flux of the gluconeogenic precursors were measured in Kenyan children with uncomplicated falciparum malaria before (n = 11) and during infusion of alanine (1.5 mg/kg.min; n = 6). Glucose production was measured by [6,6-2H2]glucose, gluconeogenesis by mass isotopomer distribution analysis of glucose labeled by [2-13C]glycerol. Basal plasma glucose concentration ...

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Publication status:
Published

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Publisher copy:
10.1210/jc.82.8.2514

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Journal:
The Journal of clinical endocrinology and metabolism
Volume:
82
Issue:
8
Pages:
2514-2521
Publication date:
1997-08-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:e8fa242e-d7e7-47de-b8c4-a2fd17a6c072
Source identifiers:
140135
Local pid:
pubs:140135

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