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Decreased 5-HT-mediated prolactin release in major depression.

Abstract:
The prolactin response to intravenous clomipramine, a 5-HT uptake inhibitor, was significantly attenuated in 12 patients with major depression. In contrast, in a further 12 depressed patients, the PRL responses to thyrotropin-releasing hormone, which acts directly on the pituitary to release PRL, were not reduced. These findings suggest that the reduction in 5-HT-mediated PRL release seen in depressed patients is due to an impairment of brain 5-HT function rather than a pituitary abnormality.
Publication status:
Published

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Publisher copy:
10.1192/bjp.160.3.372

Authors


Anderson, IM More by this author
da Roza Davis, JM More by this author
Journal:
The British journal of psychiatry : the journal of mental science
Volume:
160
Issue:
3
Pages:
372-378
Publication date:
1992-03-05
DOI:
EISSN:
1472-1465
ISSN:
0007-1250
URN:
uuid:e8f8db64-7791-4adc-8f21-dd998c822f23
Source identifiers:
185804
Local pid:
pubs:185804

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