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Reduction of the infectivity of hepatitis C virus pseudoparticles by incorporation of misfolded glycoproteins induced by glucosidase inhibitors.

Abstract:

Folding and assembly into complexes of some viral glycoproteins are exquisitely sensitive to endoplasmic reticulum (ER) alpha-glucosidase inhibition, which prevents the trimming of glucose from N-linked glycans. Derivatives of deoxynojirimycin (DNJ) iminosugars, which are potent alpha-glucosidase inhibitors, were shown to have antiviral activity against bovine viral diarrhea virus, a pestivirus related to hepatitis C virus (HCV). The aim of this study was to determine whether these inhibitors...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/vir.0.82465-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Publisher:
Microbiology Society Publisher's website
Journal:
Journal of general virology Journal website
Volume:
88
Issue:
Pt 4
Pages:
1133-1143
Publication date:
2007-04-01
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Source identifiers:
99944
Language:
English
Keywords:
Pubs id:
pubs:99944
UUID:
uuid:e8f6622d-93ec-4bee-84a6-1602df1867d6
Local pid:
pubs:99944
Deposit date:
2012-12-19

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