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Translesion synthesis: Y-family polymerases and the polymerase switch.

Abstract:

Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ...

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Publication status:
Published

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Journal:
DNA repair
Volume:
6
Issue:
7
Pages:
891-899
Publication date:
2007-07-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:e8f0581f-3cd0-4d03-b54b-4ec731ed615f
Source identifiers:
365405
Local pid:
pubs:365405

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