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Journal article

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

Abstract:

Germline mutations in the LKB1/STK11 gene cause characteristic hamartomas and freckling to develop in patients with Peutz-Jeghers syndrome (PJS). The hamartomas arise as a result of somatic "second hits" at LKB1/STK11 and therefore contain a neoplastic element. The origin of the pigmented lesions in PJS is unknown and difficult to test, as these are hardly ever biopsied. PJS patients are at increased risk of benign and malignant tumors, particularly of the colon, breast, pancreas, testis, and...

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Publication status:
Published

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Journal:
Journal of investigative dermatology More from this journal
Volume:
112
Issue:
4
Pages:
509-511
Publication date:
1999-04-01
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
Language:
English
Keywords:
Pubs id:
pubs:36894
UUID:
uuid:e8ec457e-0e1c-4b4c-b51a-fd237a2ebeeb
Local pid:
pubs:36894
Source identifiers:
36894
Deposit date:
2012-12-19

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