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Antimalarial drugs reduce cytoadherence and rosetting Plasmodium falciparum.

Abstract:

The in vivo and in vitro effects of antimalarials on cytoadherence and rosette formation were studied in 17 patients with severe and 46 with uncomplicated falciparum malaria. Cytoadherence was increased in severe malaria (P<.001 artesunate and artemether were more potent than quinine in inhibiting both adherence properties. was the most rapidly acting drug tested producing>50% inhibition of both cytoadherence and rosetting in vivo and in vitro within 2 hr of drug exposure...

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Publication status:
Published

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Publisher copy:
10.1093/infdis/173.3.691

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Journal:
Journal of infectious diseases More from this journal
Volume:
173
Issue:
3
Pages:
691-698
Publication date:
1996-03-01
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:45079
UUID:
uuid:e8e96b0d-3ad0-4b63-91dc-91738a9f1ea6
Local pid:
pubs:45079
Source identifiers:
45079
Deposit date:
2012-12-19

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