Immunological effects of IgT synthesized by theta-positive cell lines.

Journal article

The effects of immunoglobulin (Ig) purified by affinity chromatography from two cultured T cell lines on in vitro immune responses was studied. IgT purified from both EL-4 and WEHI-22 suppressed the thymus-dependent IgM response, but had no effect on the thymus-independent IgM response. In contrast, the IgG responses to both thymus-dependent and independent antigens were augmented at optimal concentrations of IgT. Ig of B cell origin--serum Ig, myeloma Ig, B cell surface Ig -- did not have any of these effects. Because of the similarity of the effects of IgT purified from the lymphomas with the effects of T cells and their IgT, it seems likely that the IgT obtained from EL-4 and WEHI-22 cell lines are analogues of normal IgT and thus should be useful in elucidating some of the chemical and biological properties of IgT.

Authors: Feldmann, M; Boylston, A; Hogg, N

• Publication status: Published
• Journal: European journal of immunology
• Volume: 5
• Issue: 6
• Pages: 429-431
• Publication date: 1976-06-01
• DOI: 10.1002/eji.1830050615
• EISSN: 1521-4141
• ISSN: 0014-2980
• Language: English
• Keywords: Animals; Mice; Immunosuppression; Lymphoma; Cell Line; Immunoglobulins; T-Lymphocytes; Immunoglobulin M; Immunoglobulin G