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Glomerular protein sieving and implications for renal failure in Fanconi syndrome.

Abstract:

BACKGROUND: Glomerular sieving coefficients (GSCs) of proteins have been measured extensively in animals but not humans. We have studied the proteinuria of Fanconi syndrome, a "knock-out" of renal tubular protein reabsorption, to estimate GSCs and detect potential contributors to development of renal failure. METHODS: Immunoassay of proteins and polypeptides in serum and urine of patients with early Dent's disease (mean GFR = 83 mL/min, range 60 to 101, N = 5), Lowe's syndrome (N = 3), and A...

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Publication status:
Published

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Volume:
60
Issue:
5
Pages:
1885-1892
Publication date:
2001-11-05
DOI:
EISSN:
1523-1755
ISSN:
0085-2538
URN:
uuid:e8d3bebd-8bc2-461d-bfaf-e61b3463fc4c
Source identifiers:
28510
Local pid:
pubs:28510

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